Simultaneous Ratio Derivative Spectrophotometric Determination of Paracetamol, Caffeine and Ibuprofen in Their Ternary Form
| Autor: | Khalaf F. Alsamarrai, Suham Tawfeq Ameen |
|---|---|
| Jazyk: | Arabic<br />English |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Baghdad Science Journal, Vol 19, Iss 6 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2078-8665 2411-7986 |
| DOI: | 10.21123/bsj.2022.6422 |
| Popis: | A new, accurate, precise and economic two spectrophotometric methods for determination of Paracetamol (Par), Ibuprofen (Ibu), and Caffeine (Caf) were suggested. Those methods were the first and second ratio derivative spectrum using a double devisor. Par, Ibu, and Caf showed many useful peaks for their quantified determination. The validity of all analysis modes for determination of the three compounds, peak to baseline, peak area and peak to peak were according to ICH. The linearity of two methods was between 5 µg/ml as a lower concentration and 50 µg/ml as the highest concentration for three compounds. Recovery percentage was around 100% and relative standard deviation was less than 2.6%. The methods were applied successfully in the determination of Par, Ibu, and Caf in pure and pharmaceutical forms. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|