Oxidative stress and fatty acid profile in Wistar rats subjected to acute food restriction and refeeding with high-fat diets

Autor: Ana Lígia da Silva Nassar, Luisa Pereira Marot, Paula Payão Ovidio, Gabriela Salim Ferreira de Castro, Alceu Afonso Jordão Júnior
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Acta Cirúrgica Brasileira, Vol 29, Iss 3, Pp 178-185 (2014)
Druh dokumentu: article
ISSN: 0102-8650
DOI: 10.1590/S0102-86502014000300006
Popis: PURPOSE: To assess oxidative stress and the profile of fatty acids incorporated into the hepatic tissue of animals refed with high-fat (HF) diets after acute food restriction.METHODS: Fifty male Wistar rats were divided into five groups and fasting for 48 hours. One group was sacrificed without refeeding (NR), a control group (C) was refed with the standard AIN-93 diet and the remaining groups with HF diets respectively consisting of hydrogenated vegetable oil (PHVO), trans-free (TF) margarine and trans-free margarine enriched with ω-3 and ω-6 (O). After this period the animals were sacrificed for malondialdehyde (MDA), catalase and hepatic fatty acid determination.RESULTS: The groups refed with HF diets showed elevation of MDA levels compared to the C group (p
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