Prevalent coinfection and associated factors for Hepatitis B, Hepatitis C, and Human Immunodeficiency Virus in patients submitted to renal replacement therapy: A cross-sectional study of 21 dialysis units in the State of Mexico

Autor: Silvia Palomo-Piñón, Neftali Eduardo Antonio-Villa, Luis Rey García-Cortés, David Rojano-Mejía, Paula González-Palomo, Marilin Victoria Martínez-Olivares, Leopoldo Santillán-Arreygué, Olga Margarita Bertadillo-Mendoza, Oliva Mejia-Rodriguez, Abraham Santos Ontiveros, Maria de los Angeles Dichi-Romero, Blanca Estela Herrera-Morales, Berenice Serafín-Méndez, Flor Araceli Nava-Ayala, Delfino Torres-Valle, Francisco Medrano-Lopez, Tabata Gabriela Aguinao-Velazquez, Antonio Aguilar de los Santos, Alfonso Hernandez Cruz, Maria Adriana Cruz-Arce, Marcos Sebastian Pineda Espinosa, Laura Mejia-Dominguez
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: PLoS ONE, Vol 17, Iss 12 (2022)
Druh dokumentu: article
ISSN: 1932-6203
41564383
Popis: Background Chronic kidney disease (CKD) predispose to viral coinfections in patients submitted to renal replacement therapy (RRT); nevertheless, few reports have been performed to elucidate the current epidemiology within this population in Mexico. Aim To estimate the prevalence of HBV, HCV, and HIV coinfection and to explore factors associated with prevalent coinfection in patients living with renal failure undergoing to RRT. Methods A multicenter cross-sectional recruitment across 21 units at the Mexican Institute of Social Security (IMSS) at the State of Mexico was performed during 2019. A standardized clinical questionnaire was performed to elucidate individual and relatives-related conditions. A treatment facility questionnaire was applied to the chief responsible of each unit to explore treatment facility variables. Serological testing, clinical, biochemical, and anthropometrical parameters were extracted from clinical records. Result In 1,304 patients (57.5% male, mean age 45.5 (SD: 15.6) years, and 95.8% in hemodialysis), the prevalence of any viral coinfection was 3.14% (95% CI: 2.32%-4.23%). The highest viral coinfection prevalence were for HCV, HBV, and HIV, in which men and subjects diagnosed after 2010’s had the highest rates. We identify that being submitted to peritoneal dialysis, being treated in a surrogated dialysis center and living with a close relative with prior hepatitis coinfection were associated factors for any viral coinfection. Conclusion In patients submitted to RRT, the prevalence of viral coinfection remains high compared with general population. Screening strategies, medical awareness and targeted public healthcare policies should prioritize better care practices within patients submitted to RRT in Mexico.
Databáze: Directory of Open Access Journals
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