Effect of Salvia officinalis L. on serum level of glucose, lipid profiles and tissue level of Malondialdehyde in diabetic rats
| Autor: | Ghosian Moghaddam MH, Roghani M, Gorjizade Z, Sadraei S |
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| Jazyk: | perština |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | مجله دانشگاه علوم پزشکی گرگان, Vol 17, Iss 2, Pp 38-44 (2015) |
| Druh dokumentu: | article |
| ISSN: | 1562-4765 2008-4080 |
| Popis: | Background and Objective: Hyperlipidemia and dyslipidemia are the prevalent risk factors associated with diabetes and their attenuation in diabetic patients with medicinal plants has great significance. This study was done to evaluate the effect of Salvia officinalis (SO) administration on serum glucose, lipids and tissue level of malondialdehyde (MDA) in streptozotocin induced diabetic rats. Methods: In this experimental study, 32 adult male Wistar rats were allocated into four groups including: control, SO-treated control, diabetic, and SO-treated diabetic groups. For induction of diabetes, a single dose of streptozotocin (60 mg/kg, i.p.) was used. SO powder was mixed with standard rat chow. Serum glucose and triglyceride, total cholesterol, LDL and HDL levels were determined on the first day and at 3rd and 6th weeks after the intervention. Finally, liver level of MDA and protein were determined in liver homogenate. Results: At 6th week, serum glucose level was significantly higher in diabetic and SO-treated diabetic groups (P |
| Databáze: | Directory of Open Access Journals |
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