Metabolic syndrome in adults with autistic traits: associated psychological, behavioral, and biological factors in females and males – a PharmLines initiative

Autor: E. B. Warreman, L. A. Nooteboom, P. J. M. Leenen, H. M. Geurts, M. B. Terry, J. H. J. Bos, E. Hak, H. W. Hoek, E. F. C. van Rossum, R. R. J. M. Vermeiren, W. A. Ester
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Frontiers in Psychiatry, Vol 14 (2023)
Druh dokumentu: article
ISSN: 1664-0640
DOI: 10.3389/fpsyt.2023.1303840
Popis: BackgroundWhile cardiovascular diseases is highly prevalent and an important cause of mortality in autistic adults, knowledge on their increased cardiovascular risk is limited. Hence, this study aimed to investigate psychological, behavioral, and physical factors associated with metabolic syndrome (MetS) in adults with autistic traits.MethodsIn total, 17,705 adults from the Lifelines Cohort were included and categorized using Autism Spectrum Quotient-10 sum-scores. The quartiles with highest (HQ-traits-group females: n = 2,635; males: n = 1803) and lowest levels of autistic traits (LQ-traits-group, n = idem) were analyzed. Using multivariable logistic regression, the associations between MetS and (self-reported and interviewed) psychological, behavioral, and physically measured factors in these stratified groups were investigated.ResultsAmong females, MetS was more common in the HQ-traits-group than in the LQ-traits-group (10.0% versus 7.5%, p
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