Ginsenosides in endometrium-related diseases: Emerging roles and mechanisms

Autor: Yang-Yang Zhang, Mao-Zhi Li, Hui-Hui Shen, Ayitila Abudukeyoumu, Feng Xie, Jiang-Feng Ye, Feng-Yuan Xu, Jian-Song Sun, Ming-Qing Li
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Biomedicine & Pharmacotherapy, Vol 166, Iss , Pp 115340- (2023)
Druh dokumentu: article
ISSN: 0753-3322
DOI: 10.1016/j.biopha.2023.115340
Popis: Ginsenosides, agents extracted from an important herb (ginseng), are expected to provide new therapies for endometrium-related diseases. Based on the molecular types of ginsenosides, we reviewed the main pharmacological effects of ginsenosides against endometrium-related diseases (e.g., endometrial cancers, endometriosis, and endometritis). The mechanism of action of ginsenosides involves inducing apoptosis of endometrium-related cells, promoting autophagy of endometrium-related cells, regulating epithelial-mesenchymal transition (EMT) in endometrium-related cells, and activating the immune system to kill cells associated with endometrial diseases. We hope to provide a theoretical foundation for the treatment of endometrium-related diseases by ginsenosides.
Databáze: Directory of Open Access Journals