Recent Developments in Glioblastoma Therapy: Oncolytic Viruses and Emerging Future Strategies

Autor: Azzam Hamad, Gaukhar M. Yusubalieva, Vladimir P. Baklaushev, Peter M. Chumakov, Anastasiya V. Lipatova
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Viruses, Vol 15, Iss 2, p 547 (2023)
Druh dokumentu: article
ISSN: 1999-4915
DOI: 10.3390/v15020547
Popis: Glioblastoma is the most aggressive form of malignant brain tumor. Standard treatment protocols and traditional immunotherapy are poorly effective as they do not significantly increase the long-term survival of glioblastoma patients. Oncolytic viruses (OVs) may be an effective alternative approach. Combining OVs with some modern treatment options may also provide significant benefits for glioblastoma patients. Here we review virotherapy for glioblastomas and describe several OVs and their combination with other therapies. The personalized use of OVs and their combination with other treatment options would become a significant area of research aiming to develop the most effective treatment regimens for glioblastomas.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje