| Autor: |
Jean-Philippe Miron, Molly Hyde, Linsay Fox, Jack Sheen, Helena Voetterl, Farrokh Mansouri, Véronique Desbeaumes Jodoin, Ryan Zhou, Sinjin Dees, Arsalan Mir-Moghtadaei, Daniel M. Blumberger, Zafiris J. Daskalakis, Fidel Vila-Rodriguez, Jonathan Downar |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Journal of Affective Disorders Reports, Vol 4, Iss , Pp 100077- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2666-9153 |
| DOI: |
10.1016/j.jadr.2021.100077 |
| Popis: |
Background: Repetitive transcranial magnetic stimulation (rTMS) is an effective intervention in major depressive disorder (MDD) but requires daily travel to a treatment clinic over several weeks. Shorter rTMS courses retaining similar effectiveness would thus increase the practicality and scalability of the technique, and therefore its accessibility. Objective: We assessed the feasibility of a novel 5 day accelerated 1 Hz rTMS protocol. We hypothesized that this novel rTMS protocol would be safe and well-tolerated while shortening the overall treatment course. Methods: We conducted a prospective, single-arm, open-label feasibility study. Thirty (30) participants received a one-week (5 days) accelerated (8 sessions per day, 40 sessions total) course of 1 Hz rTMS (600 pulses per session, 50-minute intersession interval) over the right dorsolateral prefrontal cortex (R-DLPFC) using a figure-of-eight coil at 120% of the resting motor threshold (rMT). Primary outcomes were response and remission rates on the Beck Depression Inventory-II (BDI-II). Results: Response and remission rates 1 week after treatment were 33.3% and 13.3% respectively and increased to 43.3% and 30.0% at follow-up 4 weeks after treatment. No serious adverse events occurred. All participants reported manageable pain levels. Conclusion: 1 Hz rTMS administered 8 times daily for 5 days is safe and well-tolerated. Validation in a randomized trial will be required. Trial registration: ClinicalTrials.gov Identifier: NCT04376697. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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