| Autor: |
Lin Liu, Yuntao Zhang, Xuanyang Wang, Hongxue Meng, Yan He, Xiaoqing Xu, Huan Xu, Chunbo Wei, Xuemin Yan, Xinmiao Tao, Keke Dang, Pingnan Ma, Xiaoyu Guo, Sen Yang, Jiemei Wang, Ying Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
JHEP Reports, Vol 6, Iss 8, Pp 101060- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5559 |
| DOI: |
10.1016/j.jhepr.2024.101060 |
| Popis: |
Background & Aims: There are no studies investigating the direct effects of elevated xanthine oxidase (XO) on lipid metabolism disorders. Here, we aimed to clarify the role of XO in lipid metabolism in a prospective cohort study and elucidate the underlying mechanisms. Methods: The association between serum XO activity and metabolic associated steatotic liver disease (MASLD) was examined in Cox proportional hazard models in a population-based cohort of 3,358 participants (20–75 years) at baseline. In addition, mouse models were used to investigate the underlying mechanism for the association between overexpression of XO and the lipid metabolism disorders. Results: After an average 5.8 years of follow up, we found elevated serum XO activity was associated with an increased risk of developing MASLD (hazard ratio [HR]: 2.08; 95% CI: 1.44–3.01; p-trend |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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