Characterisation of the lipolytic enzymatic activities of fungal rizoenzymes from Rhizopus oryzae in comparison to pancreatin from pigs

Autor:	Schön C., Wacker R., Rothe M., Lipowicz B., Iphöfer A.
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	rizoenzymes pancreatin exocrine pancreatic insufficiency Therapeutics. Pharmacology RM1-950
Zdroj:	European Pharmaceutical Journal, Vol 71, Iss 1, Pp 53-60 (2024)
Druh dokumentu:	article
ISSN:	2453-6725
DOI:	10.2478/afpuc-2024-0009
Popis:	In case of exocrine pancreatic insufficiency (EPI), the replacement of digestive enzymes with, for example porcine pancreatin or fungal rizoenzymes, is unavoidable under certain conditions. Current guidelines indicate that preparations from porcine pancreas have more advantageous physicochemical properties compared to those from fungi, especially at high bile salt concentrations, and that the latter can, therefore, only be used clinically to a limited extent. Since rizoenzymes are increasingly used in clinical practice, the present in vitro study investigated efficiency of enzymatic activity of rizoenzymes in comparison to pancreatin under various physiological and partly extreme environmental conditions.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/d501444b392c476a89ff7a9243dc82a0 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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