| Autor: |
Larissa Zatorre Almeida Lugo, Marco Antonio Moreira Puga, Camila Mareti Bonin Jacob, Cacilda Tezelli Junqueira Padovani, Mariana Calarge Nocetti, Maisa Souza Tupiná, Ana Flávia Silva Pina, Jennifer Naed Martins de Freitas, Alda Maria Teixeira Ferreira, Carlos Eurico Dos Santos Fernandes, Adriane Cristina Bovo, Júlio César Possati Resende, Inês Aparecida Tozetti |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 18, Iss 3, p e0279390 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0279390 |
| Popis: |
Persistent human papillomavirus (HPV) infection is closely associated with cervical carcinoma. Co-infection in the endocervical environment with other microorganisms, such as Chlamydia trachomatis, may increase the risk of HPV infection and neoplastic progression. While in some individuals, Chlamydia trachomatis infection is resolved with the activation of Th1/IFN-γ-mediated immune response, others develop a chronic infection marked by Th2-mediated immune response, resulting in intracellular persistence of the bacterium and increasing the risk of HPV infection. This work aimed to quantify cytokines of the Th1/Th2/Th17 profile in exfoliated cervix cells (ECC) and peripheral blood (PB) of patients positive for Chlamydia trachomatis DNA, patients positive for Papillomavirus DNA, and healthy patients. Cytokine levels were quantified by flow cytometry in ECC and PB samples from patients positive for C. trachomatis DNA (n = 18), patients positive for HPV DNA (n = 30), and healthy patients (n = 17) treated at the Hospital de Amor, Campo Grande-MS. After analysis, a higher concentration of IL-17, IL-6, and IL-4 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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