The effects of differing anticoagulant regimes on blood quality after cell salvage in coronary artery bypass grafting (CABG): a pilot study

Autor: Willem Boer, Mathias van Tornout, Maarten Brusseleers, Maarten Strauven, Pieter de Vooght, Margot Vander Laenen, Eric Hoste, Philippe G. Jorens
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Cardiothoracic Surgery, Vol 18, Iss 1, Pp 1-9 (2023)
Druh dokumentu: article
ISSN: 1749-8090
DOI: 10.1186/s13019-023-02246-w
Popis: Abstract Background Cell salvage reduces allogenic blood transfusion requirements in surgery. We present a pilot study exploring the impact of anticoagulant choice, citrate or heparin, on the quality of cell salvaged blood in adults undergoing coronary artery bypass grafting (CABG). Materials and methods Elective on pump CABG patients were randomly allocated to citrate or heparin anticoagulation. We measured red blood cell characteristics and inflammation in both the blood collection reservoir and the washed red blood cell concentrate. Postoperatively, the level of biomarkers and the coagulation profile in the peripheral blood as well as the transfusion requirements of allogenic blood products were studied. Results Thirty eight patients were included, 19 in the citrate group and 19 in the heparin group. Baseline characteristics were similar. In the washed red blood cell concentrate, Mean Hb (g/dl) and Ht (%) were lower in the citrate group [Hb: 18.1 g/dL (SD 1.3) vs. 21.1 (1.6), p
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