| Autor: |
Gissette Reyes, Koichi Yasunaga, Eileen Rothenstein, Wahida Karmally, Rajasekhar Ramakrishnan, Stephen Holleran, Henry N. Ginsberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 49, Iss 3, Pp 670-678 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1194/jlr.P700019-JLR200 |
| Popis: |
Postprandial hypertriglyceridemia is common in individuals with insulin resistance, and diets enriched in 1,3-diacylglycerol (DAG) may reduce postprandial plasma triglycerides (PPTGs). We enrolled 25 insulin-resistant, nondiabetic individuals in a double-blind, randomized crossover trial to test the acute and chronic effects of a DAG-enriched diet on PPTG. Participants received either DAG or triacylglycerol (TAG) oil, in food products, for 5 weeks. Fasting lipids, and two separate postprandial tests, one with DAG oil and one with TAG oil, were performed at the end of each 5 week diet period. We found no acute or chronic effects of DAG oil on PPTG. Thus, neither the DAG oil PPTG (h/mg/dl) on a chronic TAG diet [area under the curve (AUC) = 503 ± 439] nor the TAG oil PPTG on a chronic DAG diet (AUC = 517 ± 638) was different from the TAG oil PPTG on a chronic TAG diet (AUC = 565 ± 362). Five weeks of a DAG-enriched diet had no acute or chronic effects on PPTG in insulin-resistant individuals. We suggest further studies to evaluate the effects of DAG on individuals with low and high TG levels. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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