Use of almitrine in spontaneously breathing patients with COVID-19 treated with high-flow nasal cannula oxygen therapy and with persistent hypoxemia

Autor:	Clément Saccheri, Lucas Morand, Marie Juston, Denis Doyen, Hervé Hyvernat, Romain Lombardi, Raphaël Devanlay, Émilie Panicucci, Jean Dellamonica, Mathieu Jozwiak
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Acute respiratory distress syndrome Awake prone positioning COVID-19 Mechanical ventilation Oxygenation Diseases of the respiratory system RC705-779
Zdroj:	Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Druh dokumentu:	article
ISSN:	1465-993X
DOI:	10.1186/s12931-022-02308-y
Popis:	Abstract Background Almitrine, a selective pulmonary vasoconstrictor in hypoxic area, improves oxygenation in mechanically ventilated patients with COVID-19 but its effects in spontaneously breathing patients with COVID-19 remain to be determined. Methods We prospectively studied the effects of almitrine (16 µg/kg/min over 30 min followed by continuous administration in responders only) in 62 patients (66% of male, 63 [53–69] years old) with COVID-19 treated with high-flow nasal cannula oxygen therapy (HFNO) and with persistent hypoxemia, defined as a PaO2/FiO2 ratio 80% after a single awake prone positioning session. Patients with an increase in PaO2/FiO2 ratio > 20% were considered as responders. Results Overall, almitrine increased the PaO2/FiO2 ratio by 50% (p
Databáze:	Directory of Open Access Journals
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