Evaluation of risk factors for cytomegalovirus DNAemia after end of regular prophylaxis after heart transplantation

Autor: Moritz Benjamin Immohr, Daniel Oehler, Freya Sophie Jenkins, Nikolas Kalampokas, Vincent Hendrik Hettlich, Dennis Sigetti, Fabian Voß, Hannan Dalyanoglu, Hug Aubin, Payam Akhyari, Artur Lichtenberg, Udo Boeken
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Immunity, Inflammation and Disease, Vol 11, Iss 11, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2050-4527
DOI: 10.1002/iid3.1075
Popis: Abstract Background Cytomegalovirus (CMV) infections after heart transplantation (HTx) can cause cardiac allograft vasculopathy. Consequently, monitoring and prophylaxis for cytomegalovirus deoxyribonucleic acid (CMV‐DNAemia) within the first weeks after HTx is recommended. Methods All patients who underwent HTx between September 2010 and 2021 surviving the first 90 days (n = 196) were retrospectively reviewed. The patients were divided on the prevalence of CMV‐DNAemia during the first postoperative year after the end of the prophylaxis. A total of n = 35 (20.1%) developed CMV‐DNAemia (CMV group) and were compared to patients without CMV‐DNAemia (controls, n = 139). The remaining patients (n = 22) were excluded due to incomplete data. Results Positive donors and negative recipients (D+/R−) and negative donors and positive recipients (D−/R+) serology was significantly increased and D−/R− decreased in the CMV group (p
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