Gut microbiome-mediated metabolism effects on immunity in rural and urban African populations

Autor: Martin Stražar, Godfrey S. Temba, Hera Vlamakis, Vesla I. Kullaya, Furaha Lyamuya, Blandina T. Mmbaga, Leo A. B. Joosten, Andre J. A. M. van der Ven, Mihai G. Netea, Quirijn de Mast, Ramnik J. Xavier
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-25213-2
Popis: The authors profile stool metagenomics and plasma metabolomics in Tanzanian individuals and uncover a gradient of gut microbial profiles, from rural through urban Tanzania towards Western populations. Integration with ex vivo blood microbial stimulations reveals immune responses associated with histidine and arginine pathways, mediated by Bifidobacterium longum and Akkermansia muciniphila.
Databáze: Directory of Open Access Journals