Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children.

Autor: Rivka M Lim, Mark E J Woolhouse, Takafira Mduluza, Margo Chase-Topping, Derick N M Osakunor, Lester Chitsulo, Francisca Mutapi
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008650 (2020)
Druh dokumentu: article
ISSN: 1935-2727
1935-2735
DOI: 10.1371/journal.pntd.0008650
Popis: In 2012, the World Health Organisation (WHO) set out a roadmap for eliminating schistosomiasis as a public health problem by 2025. To achieve this target, preschool-aged children (PSAC; aged 6 years and below) will need to be included in schistosomiasis treatment programmes. As the global community discusses the tools and approaches for treating this group, one of the main questions that remains unanswered is how to quantify infection in this age group to inform treatment strategies. The aim of this study was thus to determine whether a relationship exists between levels of schistosome infection in PSAC and school-aged children (SAC), that can be used to determine unknown schistosome infection prevalence levels in PSAC. A systematic search of publications reporting schistosomiasis prevalence in African PSAC and SAC was conducted. The search strategy was formulated using the PRISMA guidelines and SPIDER search strategy tool. The published data was subjected to regression analysis to determine if a relationship exists between infection levels in PSAC and SAC. The interaction between SAC and community treatment history was also entered in the regression model to determine if treatment history significantly affected the relationship between PSAC and SAC prevalence. The results showed that a significant positive relationship exists between infection prevalence levels in PSAC and SAC for Schistosoma mansoni (r = 0.812, df (88, 1), p =
Databáze: Directory of Open Access Journals
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