| Autor: |
Yu Pi, Xiangyu Zhang, Yujun Wu, Zhenyu Wang, Yu Bai, Xiaoyi Liu, Dandan Han, Jinbiao Zhao, Isabel Tobin, Jiangchao Zhao, Guolong Zhang, Junjun Wang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Microbiology Spectrum, Vol 10, Iss 6 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2165-0497 |
| DOI: |
10.1128/spectrum.02979-22 |
| Popis: |
ABSTRACT Alginate (ALG) is known to alleviate intestinal inflammation in inflammatory bowel disease, but its mechanism of action remains elusive. In the present study, we studied the involvement of the intestinal microbiota and bile acid (BA) metabolism in ALG-mediated anti-inflammatory effects in mice. A combination of 16S rRNA gene amplicon sequencing, shotgun metagenomic sequencing, and targeted BA metabolomic profiling was employed to investigate structural and functional differences in the colonic microbiota and BA metabolism in dextran sulfate sodium (DSS)-treated mice with or without dietary supplementation of ALG. We further explored the role of the intestinal microbiota as well as a selected ALG-enriched bacterium and BA in DSS-induced colitis. Dietary ALG alleviated DSS-mediated intestinal inflammation and enriched a small set of bacteria including Bifidobacterium animalis in the colon (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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