Immunogenic cell death‐inducing small molecule inhibitors: Potential for immunotherapy of cancer

Autor: Zong Sheng Guo, Pawel Kalinski, Hongqi Chen, Zhi Zhu
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Clinical and Translational Discovery, Vol 2, Iss 2, Pp n/a-n/a (2022)
Druh dokumentu: article
ISSN: 2768-0622
DOI: 10.1002/ctd2.69
Popis: Abstract Small molecule inhibitors (SMIs) of key signalling pathways are known to induce multiple types of regulated cell death, including immunogenic cell death (ICD). The resulting antitumor immunity helps to overcome the resistance of cancer cells to cell death, resulting in improved cancer therapy. SMIs, especially those inducing multimodal cell death and ICD, can be critical components in rational combinations for cancer immunotherapy.
Databáze: Directory of Open Access Journals