Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
| Autor: | Selin Akpinar Adscheid, Akif E. Türeli, Nazende Günday-Türeli, Marc Schneider |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: |
antibody delivery
biopharmaceutical delivery blood–brain barrier (bbb) cns diseases drug delivery hybrid nanoparticles intranasal delivery liposomes nanomedicine nanostructured lipid carriers (nlcs) polymer nanoparticles rna delivery solid lipid nanoparticles (slns) Technology Chemical technology TP1-1185 Science Physics QC1-999 |
| Zdroj: | Beilstein Journal of Nanotechnology, Vol 15, Iss 1, Pp 1400-1414 (2024) |
| Druh dokumentu: | article |
| ISSN: | 2190-4286 |
| DOI: | 10.3762/bjnano.15.113 |
| Popis: | Central nervous system diseases negatively affect patients and society. Providing successful noninvasive treatments for these diseases is challenging because of the presence of the blood–brain barrier. While protecting the brain’s homeostasis, the barrier limits the passage of almost all large-molecule drugs and most small-molecule drugs. A noninvasive method, nose-to-brain delivery (N2B delivery) has been proposed to overcome this challenge. By exploiting the direct anatomical interaction between the nose and the brain, the drugs can reach the target, the brain. Moreover, the drugs can be encapsulated into various drug delivery systems to enhance physicochemical characteristics and targeting success. Many preclinical data show that this strategy can effectively deliver biopharmaceuticals to the brain. Therefore, this review focuses on N2B delivery while giving examples of different drug delivery systems suitable for the applications. In addition, we emphasize the importance of the effective delivery of monoclonal antibodies and RNA and stress the recent literature tackling this challenge. While giving examples of nanotechnological approaches for the effective delivery of small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations. |
| Databáze: | Directory of Open Access Journals |
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