Fortifying angiogenic efficacy of conditioned media using phototoxic‐free blue light for wound healing

Autor:	Sung‐Won Kim, Gwang‐Bum Im, Yeong Hwan Kim, Suk Ho Bhang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	angiogenesis bOLED conditioned medium phototoxicity ROS Chemical engineering TP155-156 Biotechnology TP248.13-248.65 Therapeutics. Pharmacology RM1-950
Zdroj:	Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
Druh dokumentu:	article
ISSN:	2380-6761
DOI:	10.1002/btm2.10462
Popis:	Abstract We used a blue organic light‐emitting diode (bOLED) to increase the paracrine factors secreted from human adipose‐derived stem cells (hADSCs) for producing conditioned medium (CM). Our results showed that while the bOLED irradiation promotes a mild‐dose reactive oxygen generation that enhances the angiogenic paracrine secretion of hADSCs, it does not induce phototoxicity. The bOLED enhances paracrine factors via a cell‐signaling mechanism involving hypoxia‐inducible factor 1 alpha. This study demonstrated that the CM resulting from bOLED treatment shows improved therapeutic effects on mouse wound‐healing models. This method contributes to overcoming the barriers to stem‐cell therapies, including the toxicity and low yields from other methods such as nanoparticles, synthetic polymers, and even cell‐derived vesicles.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4f971bdda123437dbdd2184e40b44cbe Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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