| Autor: |
João Arthur Alcântara, Francys Sayara Andrade de Araújo, Andréia da Costa Paz, Rodrigo Maciel Alencar, Berta Yoná de Albuquerque Caldas, Raquel Soares Maia Godoy, Marcus Vinicius Guimarães Lacerda, Gisely Cardoso de Melo, Wuelton Marcelo Monteiro, Vanderson de Souza Sampaio, Nágila Francinete Costa Secundino, Ana Paula Marques Duarte, Rosa Amélia Gonçalves Santana, Paulo Filemon Paolucci Pimenta |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1475-2875 |
| DOI: |
10.1186/s12936-023-04767-0 |
| Popis: |
Abstract Background Reducing mosquito abundance or interfering with its ability to support the parasite cycle can help to interrupt malaria in areas of significant risk of malaria transmission. Fluralaner is a safe and effective drug for veterinary use indicated for the treatment against fleas and ticks which acts as an antagonist of chloride ion channels mediated by γ-aminobutyric acid (GABA), preventing the entry of these ions into the postsynaptic neuron, leading to hyperexcitability of the postsynaptic neuron of the central nervous system of arthropods. Fluralaner demonstrated insecticidal activity against different insect species. Methods The study aimed to evaluate the effects of fluralaner on the biology, survival, and reproductive fitness of Anopheles aquasalis. The following lethal concentrations (LC) were determined for An. aquasalis: LC5 = 0.511 µM; LC25 = 1.625 µM; LC50 = 3.237 µM. Results A significant decrease (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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