| Autor: |
Hiroshi Takahashi, Yasuchika Aoki, Junya Saito, Arata Nakajima, Masato Sonobe, Yorikazu Akatsu, Shinji Taniguchi, Manabu Yamada, Keita Koyama, Yuki Akiyama, Yasuhiro Shiga, Kazuhide Inage, Sumihisa Orita, Yawara Eguchi, Satoshi Maki, Takeo Furuya, Tsutomu Akazawa, Masao Koda, Masashi Yamazaki, Seiji Ohtori, Koichi Nakagawa |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Musculoskeletal Disorders, Vol 20, Iss 1, Pp 1-10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2474 |
| DOI: |
10.1186/s12891-019-2966-5 |
| Popis: |
Abstract Background Recent reports indicate that oxidative stress induced by reactive oxygen species is associated with the pathobiology of neurodegenerative disorders that involve neuronal cell apoptosis. Here we conducted a cross-sectional study to evaluate serum levels of oxidative stress in cervical compression myelopathy. Methods Thirty-six serum samples were collected preoperatively from patients treated for acutely worsening compression myelopathy (AM) and chronic compression myelopathy (CM). Serum levels of oxidative stress markers were evaluated by measuring derivatives of reactive oxygen metabolites (ROM), which reflect concentrations of hydroperoxides. ROM in healthy individuals range from 250 to 300 (U. CARR), whereas ROM >340–400 and > 400 define moderate and severe levels of oxidative stress, respectively. Difference of ROM by the cause of disorders whether cervical spondylotic myelopathy (CSM) or cervical ossification of longitudinal ligament (OPLL), correlations between ROM and patient age, body mass index (BMI), history of smoking, existence of diabetes were examined. Neurological evaluations according to Japanese Orthopaedic Association (JOA) scores were performed and correlated with ROM. Results ROM increased to 349.5 ± 54.8, representing a moderate oxidative stress, in CM samples. ROM increased to 409.2 ± 77.9 in AM samples, reflecting severe oxidative stress which were significantly higher than for CM samples (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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