| Autor: |
Claudia Ielo, Francesca Fazio, Serena Rocchi, Ilaria Rizzello, Katia Mancuso, Elena Zamagni, Michele Cavo, Maria Teresa Petrucci |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Leukemia Research Reports, Vol 21, Iss , Pp 100399- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2213-0489 |
| DOI: |
10.1016/j.lrr.2023.100399 |
| Popis: |
Chimeric antigen receptor (CAR) T-cells have unveiled a promising therapeutic horizon for relapsed/refractory multiple myeloma (R/R MM). Nevertheless, immune impairment induced by cellular therapies, previous treatments and MM itself could promote infectious events. COVID-19 could evolve into a life-threating infection in R/R MM patients who often have suboptimal responses to SARS-CoV-2 vaccines. Here, we describe a case of severe and long-lasting COVID-19 pneumonia after CAR T-cell therapy for R/R MM requiring a complex clinical management. Long-term infectious complications in MM patients undergoing CAR T-cells should be taken into consideration as they could counteract the efficacy of this new treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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