Autor: |
Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman |
Jazyk: |
angličtina |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019) |
Druh dokumentu: |
article |
ISSN: |
2041-1723 |
DOI: |
10.1038/s41467-019-08965-w |
Popis: |
Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity between the estrogen receptor and the beta-tubulin taxane binding pocket. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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