Advances in the treatment of atherosclerosis with ligand‐modified nanocarriers

Autor: Xiujiao Deng, Jinghao Wang, Shanshan Yu, Suiyi Tan, Tingting Yu, Qiaxin Xu, Nenghua Chen, Siqi Zhang, Ming‐Rong Zhang, Kuan Hu, Zeyu Xiao
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Exploration, Vol 4, Iss 3, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2766-2098
2766-8509
DOI: 10.1002/EXP.20230090
Popis: Abstract Atherosclerosis, a chronic disease associated with metabolism, poses a significant risk to human well‐being. Currently, existing treatments for atherosclerosis lack sufficient efficiency, while the utilization of surface‐modified nanoparticles holds the potential to deliver highly effective therapeutic outcomes. These nanoparticles can target and bind to specific receptors that are abnormally over‐expressed in atherosclerotic conditions. This paper reviews recent research (2018–present) advances in various ligand‐modified nanoparticle systems targeting atherosclerosis by specifically targeting signature molecules in the hope of precise treatment at the molecular level and concludes with a discussion of the challenges and prospects in this field. The intention of this review is to inspire novel concepts for the design and advancement of targeted nanomedicines tailored specifically for the treatment of atherosclerosis.
Databáze: Directory of Open Access Journals
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