| Autor: |
Juliana Woyames, Isabela de Lima Martins, Manuella Soares de Souza, Cherley Borba Vieira de Andrade, Georgia Atella, Isis Hara Trevenzoli, Carmen Cabanelas Pazos-Moura |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 119, Iss , Pp 106304- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2024.106304 |
| Popis: |
Perinatal maternal high-fat (HF) diet induces metabolic disorders in offspring associated with mitochondrial damage in their skeletal muscle. We hypothesized that gestational supplementation with fish oil (FO), rich in n-3 polyunsaturated fatty acids, may attenuate mitochondrial injury in the soleus muscle of male and female weanling HF offspring. Female rats received control or HF diet from 8 weeks premating throughout lactation. During gestation, part of HF dams received HF diet containing 3 % FO. Gestational FO mitigated HF-induced soleus sarcomere misalignment and mitochondrial ultrastructural injury in weanling offspring. FO increased mitochondrial complex proteins I and III in males and uncoupling protein-3 and PGC1α (biogenesis marker) in both sexes. FO enhanced fusion proteins mitofusin-2 (males) and OPA-1 (females) and mitochondrial size, suggesting increased mitochondrial fusion. Thus, gestational FO supplementation to maternal HF diet enhances biogenesis and mitochondrial fusion markers, improving mitochondria quality and potentially function in soleus muscle of weanling HF offspring. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect