gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes

Autor:	Nancy Q. Liu, Yucheng Lin, Liangliang Li, Jinxiu Lu, Dawei Geng, Jiankang Zhang, Tea Jashashvili, Zorica Buser, Jenny Magallanes, Jade Tassey, Ruzanna Shkhyan, Arijita Sarkar, Noah Lopez, Siyoung Lee, Youngjoo Lee, Liming Wang, Frank A. Petrigliano, Ben Van Handel, Karen Lyons, Denis Evseenko
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Biology (General) QH301-705.5
Zdroj:	Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)
Druh dokumentu:	article
ISSN:	2399-3642
DOI:	10.1038/s42003-021-02944-y
Popis:	Liu et al. demonstrate the role of gp130/STAT3 signalling in the development and homeostasis of chondrocytes in the growth plate and articular cartilage. The authors report that tamoxifen-induced deletion of STAT3 or gp130 in chondrocytes after birth results in defective chondrocyte proliferation, growth plate fusion and stunting, and signs of progressive dysfunction of the articular cartilage, with female mice more strongly affected than males.
Databáze:	Directory of Open Access Journals
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