Clinical impact of fungal colonization of burn wounds in patients hospitalized in the intensive care unit: a retrospective cohort study

Autor: Ivan Gur, Anton Zilbert, Kochava Toledano, Michael Roimi, Anat Stern
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Druh dokumentu: article
ISSN: 2397-5776
DOI: 10.1136/tsaco-2023-001325
Popis: Background Invasive fungal infections in burn victims significantly increase mortality and hospitalization. The effect of fungal burn wound colonization has not been established.Methods All adult patients hospitalized in the intensive care unit (ICU) with burns ≥10% of total body surface area (TBSA) between 2005 and 2021 were included. Superficial swabs were collected whenever clinical suspicion of wound colonization was raised, and deep tissue samples were sent at any wound excision. The primary outcome was the incidence of invasive fungal infections defined as any deep tissue fungal infection or fungemia.Results Of 242 patients included, 39 (16.1%) had fungal wound colonization, 22 (56.4%) with yeasts and 24 (61.5%) molds. Patients with fungal colonization had a significantly higher rate of invasive fungal infections (82.1% vs 3.9%, p
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