Improvement of cognitive function by escitalopram and paroxetine in patients with first-episode depressive disorder and its relationship with thyroid hormone levels

Autor: Zhao Mingming, Ma Jiahui, Li Chao, Niu Gengyun, Wang Zhifei, Liu Zengxun
Jazyk: čínština
Rok vydání: 2023
Předmět:
Zdroj: Sichuan jingshen weisheng, Vol 36, Iss 3, Pp 222-227 (2023)
Druh dokumentu: article
ISSN: 1007-3256
DOI: 10.11886/scjsws20221008001
Popis: BackgroundThe incidence of cognitive impairment in patients with depressive disorder is high, and the causes and mechanisms of which deserve more attention. It is usual that the thyroid hormone levels in patients with depressive disorder alter. Further research is needed to explore whether the cognitive function changes in patients with depressive disorder are related to thyroid hormone levels.ObjectiveTo explore the improvement of cognitive function in patients with first-episode depressive disorder after escitalopram and paroxetine treatment, and to analyse its correlation with thyroid hormone levels, so as to look for potential biomarkers of cognitive function change in patients with depressive disorder.MethodsFrom March 2021 to March 2022, 120 patients who met the diagnostic criteria of the International Classification of Diseases, tenth edition (ICD-10) for depression and were hospitalized at Shandong Mental Health Center were selected as the research objects. They were randomly divided into two groups by random number table method with 60 patients in each group. The two groups were treated with escitalopram (starting dose 5 mg/d) and paroxetine (starting dose 20 mg/d) for 6 weeks. Before and 6 weeks after the treatment, levels of thyroid stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were tested respectively. Depression degree and cognitive function level were assessed using the Hamilton Depression Scale-17 item (HAMD-17) and Montreal Cognitive Assessment (MoCA), respectively. Pearson or Spearman correlation analysis was used to examine the correlation between the MoCA score difference before and after the treatment and the post-treatment level of thyroid hormone.ResultsBefore and 6 weeks after the treatment, the time effect of HAMD-17 total score in both groups was statistically significant (F=1 236.568, P
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