| Autor: |
A. Aramburo, Jim Todd, Elizabeth C. George, Sarah Kiguli, Peter Olupot-Olupot, Robert O. Opoka, Charles Engoru, Samuel O. Akech, Richard Nyeko, George Mtove, Diana M. Gibb, Abdel G. Babiker, Kathryn Maitland |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
BMC Medicine, Vol 16, Iss 1, Pp 1-12 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1741-7015 |
| DOI: |
10.1186/s12916-018-1014-x |
| Popis: |
Abstract Background Hyperlactataemia (HL) is a biomarker of disease severity that predicts mortality in patients with sepsis and malaria. Lactate clearance (LC) during resuscitation has been shown to be a prognostic factor of survival in critically ill adults, but little data exist for African children living in malaria-endemic areas. Methods In a secondary data analysis of severely ill febrile children included in the Fluid Expansion as Supportive Therapy (FEAST) resuscitation trial, we assessed the association between lactate levels at admission and LC at 8 h with all-cause mortality at 72 h (d72). LC was defined as a relative lactate decline ≥ 40% and/or lactate normalisation (lactate |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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