Molecular signatures of aneuploidy-driven adaptive evolution

Autor: Alaattin Kaya, Marco Mariotti, Alexander Tyshkovskiy, Xuming Zhou, Michelle L. Hulke, Siming Ma, Maxim V. Gerashchenko, Amnon Koren, Vadim N. Gladyshev
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-13669-2
Popis: Aneuploidy (abnormal chromosome number) can enable rapid adaptation to stress conditions, but it also entails fitness costs from gene imbalance. Here, the authors experimentally evolve yeast while forcing maintenance of aneuploidy to identify the mechanisms that promote tolerance of aneuploidy.
Databáze: Directory of Open Access Journals