IL-10 suppresses T cell expansion while promoting tissue-resident memory cell formation during SARS-CoV-2 infection in rhesus macaques.

Autor: Christine E Nelson, Taylor W Foreman, Eduardo R Fukutani, Keith D Kauffman, Shunsuke Sakai, Joel D Fleegle, Felipe Gomez, NIAID/DIR Tuberculosis Imaging Program, Sydnee T Gould, Cyril Le Nouën, Xueqiao Liu, Tracey L Burdette, Nicole L Garza, Bernard A P Lafont, Kelsie Brooks, Cecilia S Lindestam Arlehamn, Daniela Weiskopf, Alessandro Sette, Heather D Hickman, Ursula J Buchholz, Reed F Johnson, Jason M Brenchley, James P Oberman, Artur T L Quieroz, Bruno B Andrade, Laura E Via, Daniel L Barber
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: PLoS Pathogens, Vol 20, Iss 7, p e1012339 (2024)
Druh dokumentu: article
ISSN: 1553-7366
1553-7374
DOI: 10.1371/journal.ppat.1012339
Popis: The regulation of inflammatory responses and pulmonary disease during SARS-CoV-2 infection is incompletely understood. Here we examine the roles of the prototypic pro- and anti-inflammatory cytokines IFNγ and IL-10 using the rhesus macaque model of mild COVID-19. We find that IFNγ drives the development of 18fluorodeoxyglucose (FDG)-avid lesions in the lungs as measured by PET/CT imaging but is not required for suppression of viral replication. In contrast, IL-10 limits the duration of acute pulmonary lesions, serum markers of inflammation and the magnitude of virus-specific T cell expansion but does not impair viral clearance. We also show that IL-10 induces the subsequent differentiation of virus-specific effector T cells into CD69+CD103+ tissue resident memory cells (Trm) in the airways and maintains Trm cells in nasal mucosal surfaces, highlighting an unexpected role for IL-10 in promoting airway memory T cells during SARS-CoV-2 infection of macaques.
Databáze: Directory of Open Access Journals
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