Multi‐site Investigation of Genetic Determinants of Warfarin Dose Variability in Latinos

Autor: Nihal El Rouby, Leiliane Rodrigues Marcatto, Karla Claudio, Letícia Camargo Tavares, Heidi Steiner, Marianna R. Botton, Steve A. Lubitz, Echo N. Fallon, Kevin Yee, Justin Kaye, Stuart A. Scott, Jason Karnes, Paulo Caleb Junior de Lima Santos, Jorge Duconge, Larisa H. Cavallari
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Clinical and Translational Science, Vol 14, Iss 1, Pp 268-276 (2021)
Druh dokumentu: article
ISSN: 1752-8062
1752-8054
DOI: 10.1111/cts.12854
Popis: We conducted a multi‐site investigation of genetic determinants of warfarin dose variability in Latinos from the U.S. and Brazil. Patients from four institutions in the United States (n = 411) and Brazil (n = 663) were genotyped for VKORC1 c.‐1639G> A, common CYP2C9 variants, CYP4F2*3, and NQO1*2. Multiple regression analysis was used in the U.S. cohort to test the association between warfarin dose and genotype, adjusting for clinical factors, with further testing in an independent cohort of Brazilians. In the U.S. cohort, VKORC1 and CYP2C9 variants were associated with lower warfarin dose (β = −0.29, P
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