FIB-4 and APRI for cirrhosis detection in a privately insured national cohort

Autor: Neehar D. Parikh, Manaav Mehta, Elliot B. Tapper
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: JHEP Reports, Vol 6, Iss 1, Pp 100925- (2024)
Druh dokumentu: article
ISSN: 2589-5559
DOI: 10.1016/j.jhepr.2023.100925
Popis: Background and Aims: Non-invasive laboratory-based fibrosis indices have been proposed as a tool for population-based screening for advanced fibrosis. We aimed to examine the performance of fibrosis indices at the time of and prior to cirrhosis diagnosis. Methods: We included adult patients with cirrhosis diagnosis codes in a privately insured database (Optum) from 2010-2018 with 1:4 birth year-matched controls without cirrhosis diagnosis codes. We analyzed aspartate aminotransferase-to-platelet ratio index (APRI), and fibrosis-4 index (FIB-4) up to 30 months prior to the entry of cirrhosis diagnosis codes. Cut-offs of
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