| Autor: |
Julia Kozlitina, Naomi M. Cohen, Drew Sturtevant, Jonathan C. Cohen, Cathi Murphey-Half, Jerome G. Saltarrelli, Peter Jindra, Medhat Askar, Christine S. Hwang, Parsia A. Vagefi, Chantale Lacelle, Helen H. Hobbs, Malcolm P. MacConmara |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
EClinicalMedicine, Vol 67, Iss , Pp 102350- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2589-5370 |
| DOI: |
10.1016/j.eclinm.2023.102350 |
| Popis: |
Summary: Background: Several genetic variants are associated with chronic liver disease. The role of these variants in outcomes after liver transplantation (LT) is uncertain. The aim of this study was to determine if donor genotype at risk-associated variants in PNPLA3 (rs738409 C>G, p.I148M) and HSD17B13 (rs72613567 T>TA; rs80182459, p.A192Lfs∗8) influences post-LT survival. Methods: In this retrospective cohort study, data on 2346 adults who underwent first-time LT between January 1, 1999 and June 30, 2020 and who had donor DNA samples available at five large Transplant Immunology Laboratories in Texas, USA, were obtained from the United Network for Organ Sharing (UNOS). Duplicates, patients with insufficient donor DNA for genotyping, those who were |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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