| Autor: |
Mahlon D. Johnson, David N. Korones, Hazrati L-N, Kevin Walter, Ali Hussain |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Interdisciplinary Neurosurgery, Vol 20, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-7519 |
| DOI: |
10.1016/j.inat.2019.100634 |
| Popis: |
The development of Ewing's sarcoma (ES) as an intradural, extramedullary cervical spinal cord tumor is uncommon. It is particularly rare in a middle-aged adult. We describe the clinical, pathological and genetic features in a 42 year old male with a 3 month history of arm weakness. MRI of the cervical spine with and without contrast revealed an intradural, extra-axial enhancing lesion involving the spinal canal from the foramen magnum to the level of C4. Partial surgical resection revealed a malignant neuroepithelial tumor. Genetic analysis identified a EWSRA-FLI1 (exon 7-exon 6) fusion, transcript suggesting classification as a Ewing's sarcoma/primitive neuroectodermal tumor. The case highlights the variability in the presentation of ES and value of genetic testing in atypical “blue cell” tumors. Keywords: Ewing's sarcoma, Cervical spinal cord, Adult, Genetics |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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