A regulatory role for CD72 expression on B cells and increased soluble CD72 in primary Sjogren’s syndrome

Autor: Yuqi Shen, Yuhua Ma, Jingyuan Xie, Li Lin, Yifan Shi, Xiao Li, Pingyan Shen, Xiaoxia Pan, Hong Ren
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: BMC Immunology, Vol 21, Iss 1, Pp 1-6 (2020)
Druh dokumentu: article
ISSN: 1471-2172
16316959
DOI: 10.1186/s12865-020-00351-2
Popis: Abstract Background CD72, a co-receptor of B cell receptor (BCR), has been reported to have both positive and negative effects on B cell functions in several immunological diseases. The B cell plays an important role in the pathogenesis of primary Sjogren’s syndrome (pSS). However, whether CD72 is involved in the process remains unknown. This study aimed to observe the possible role of CD72 in the pathogenesis of pSS. Results A total of 60 cases who fulfilled the American-European Consensus Group (AECG) criteria for the diagnosis of pSS and 61 gender and age-matched healthy controls were recruited in this study. The percentage of CD72+ B cells was 85.31 ± 8.37% in pSS patients and 76.91 ± 8.50% in healthy controls(p
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