| Autor: |
Alex Hatzimanolis, Sarah Tosato, Mirella Ruggeri, Doriana Cristofalo, Leonidas Mantonakis, Lida-Alkisti Xenaki, Stefanos Dimitrakopoulos, Mirjana Selakovic, Stefania Foteli, Ioannis Kosteletos, Ilias Vlachos, Rigas-Filippos Soldatos, Nikos Nianiakas, Irene Ralli, Konstantinos Kollias, Angeliki-Aikaterini Ntigrintaki, Pentagiotissa Stefanatou, Robin M. Murray, Evangelos Vassos, Nikos C. Stefanis |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Translational Psychiatry, Vol 14, Iss 1, Pp 1-8 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2158-3188 |
| DOI: |
10.1038/s41398-024-02750-0 |
| Popis: |
Abstract Insufficiency of vitamin D levels often occur in individuals with schizophrenia and first-episode psychosis (FEP). However, it is unknown whether this represents a biological predisposition, or it is essentially driven by illness-related alterations in lifestyle habits. Lower vitamin D has also been associated with adverse neurodevelopmental outcomes and predominant negative psychotic symptoms. This study aimed to investigate the contribution of polygenic risk score for circulating 25-hydroxyvitamin D concentration (PRS-vitD) to symptom presentation among individuals with FEP enrolled in the Athens First-Episode Psychosis Research Study (AthensFEP n = 205) and the Psychosis Incident Cohort Outcome Study (PICOS n = 123). The severity of psychopathology was evaluated using the Positive and Negative Syndrome Scale at baseline and follow-up assessments (AthensFEP: 4-weeks follow-up, PICOS: 1-year follow-up). Premorbid intelligence and adjustment domains were also examined as proxy measures of neurodevelopmental deviations. An inverse association between PRS-vitD and severity of negative symptoms, in particular lack of social motivation, was detected in the AthensFEP at baseline (adjusted R 2 = 0.04, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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