Four New Gallate Derivatives from Wine-Processed Corni Fructus and Their Anti-Inflammatory Activities
| Autor: | Hong-Bin Li, Qing-Mei Feng, Ling-Xia Zhang, Jing Wang, Jun Chi, Sui-Qing Chen, Zhi-Min Wang, Li-Ping Dai, Er-Ping Xu |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Molecules, Vol 26, Iss 7, p 1851 (2021) |
| Druh dokumentu: | article |
| ISSN: | 26071851 1420-3049 |
| DOI: | 10.3390/molecules26071851 |
| Popis: | Four new gallate derivatives—ornusgallate A, ent-cornusgallate A, cornusgallate B and C (1a, 1b, 2, 3)—were isolated from the wine-processed fruit of Cornus officinalis. Among them, 1a and 1b are new natural compounds with novel skeletons. Their chemical structures were elucidated by comprehensive spectroscopy methods including NMR, IR, HRESIMS, UV, ECD spectra and single-crystal X-ray diffraction analysis. The in vitro anti-inflammatory activities of all compounds were assayed in RAW 264.7 cells by assessing LPS-induced NO production. As the result, all compounds exhibited anti-inflammatory activities at attested concentrations. Among the tested compounds, compound 2 exhibited the strongest anti- inflammatory activity. |
| Databáze: | Directory of Open Access Journals |
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