β-Herpesviruses in Febrile Children with Cancer
| Autor: | Stephanie Yee-Guardino, Kate Gowans, Belinda Yen-Lieberman, Pamela Berk, Debra Kohn, Fu-Zhang Wang, Lara Danziger-Isakov, Camille Sabella, Sarah Worley, Philip E. Pellett, Johanna Goldfarb |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Emerging Infectious Diseases, Vol 14, Iss 4, Pp 579-585 (2008) |
| Druh dokumentu: | article |
| ISSN: | 1080-6040 1080-6059 |
| DOI: | 10.3201/eid1404.070651 |
| Popis: | We conducted a cross-sectional study of β-herpesviruses in febrile pediatric oncology patients (n = 30), with a reference group of febrile pediatric solid-organ transplant recipients (n = 9). One (3.3%) of 30 cancer patients and 3 (33%) of 9 organ recipients were PCR positive for cytomegalovirus. Four (13%) of 30 cancer patients and 3 (33%) of 9 transplant recipients had human herpesvirus 6B (HHV-6B) DNAemia, which was more common within 6 months of initiation of immune suppression (4 of 16 vs. 0 of 14 cancer patients; p = 0.050). HHV-6A and HHV-7 were not detected. No other cause was identified in children with HHV-6B or cytomegalovirus DNAemia. One HHV-6B–positive cancer patient had febrile disease with concomitant hepatitis. Other HHV-6B–positive children had mild “viral” illnesses, as did a child with primary cytomegalovirus infection. Cytomegalovirus and HHV-6B should be included in the differential diagnosis of febrile disease in children with cancer. |
| Databáze: | Directory of Open Access Journals |
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