Valsartan- and melatonin-supported adipose-derived mesenchymal stem cells preserve renal function in chronic kidney disease rat through upregulation of prion protein participated in promoting PI3K-Akt-mTOR signaling and cell proliferation

Autor: Chih-Chao Yang, Pei-Hsun Sung, Kuan-Hung Chen, Han-Tan Chai, John Y. Chiang, Sheung-Fat Ko, Fan-Yen Lee, Hon-Kan Yip
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112551- (2022)
Druh dokumentu: article
ISSN: 0753-3322
19429959
DOI: 10.1016/j.biopha.2021.112551
Popis: This study tested the hypothesis that valsartan (Val) and melatonin (Mel)-assisted adipose-derived mesenchymal stem cells (ADMSCs) preserved the residual renal function in chronic kidney disease (CKD) rat through promoting cellular-prior-protein (PrPC) to upregulate PI3K/Akt/mTOR signaling and cell proliferation. In vitro study demonstrated that as compared with CKD-derived-ADMSCs, Val/Mel/overexpression of PrPC-treated CKD derived-ADMSCs significantly upregulated cell proliferation and protein expressions of PrPC and phosphorylated (p)-PI3K/p-Akt/p-mTOR, and downregulated oxidative stress (all p
Databáze: Directory of Open Access Journals
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