| Autor: |
Ellen Van Damme, Kris Laukens, Thanh Hai Dang, Xaveer Van Ostade |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
International Journal of Biological Sciences, Vol 6, Iss 1, Pp 51-67 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1449-2288 |
| Popis: |
Promyelocytic Leukaemia Protein nuclear bodies (PML-NBs) are dynamic nuclear protein aggregates. To gain insight in PML-NB function, reductionist and high throughput techniques have been employed to identify PML-NB proteins. Here we present a manually curated network of the PML-NB interactome based on extensive literature review including database information. By compiling 'the PML-ome', we highlighted the presence of interactors in the Small Ubiquitin Like Modifier (SUMO) conjugation pathway. Additionally, we show an enrichment of SUMOylatable proteins in the PML-NBs through an in-house prediction algorithm. Therefore, based on the PML network, we hypothesize that PML-NBs may function as a nuclear SUMOylation hotspot. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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