Prognostic significance of smac/DIABLO in endometrioid endometrial cancer

Autor:	Bozena Dobrzycka, Slawomir J. Terlikowski, Piotr S. Bernaczyk, Magdalena Garbowicz, Jacek Niklinski, Lech Chyczewski, Marek Kulikowski
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	endometrioid endometrial cancer smac/DIABLO prognosis Cytology QH573-671
Zdroj:	Folia Histochemica et Cytobiologica, Vol 48, Iss 4, Pp 678-681 (2010)
Druh dokumentu:	article
ISSN:	0239-8508 1897-5631
Popis:	Apoptosis may occur via a death receptor-dependent or independent (mitochondrial) pathway. The mitochondrialpathway is regulated by small molecules, such as smac/Diablo, which activates caspase cascades. This study examinedsmac/DIABLO expression in 76 patients with endometrioid endometrial cancers. Presence of smac/DIABLO was quantifiedby Western blot analysis using nonfixed fresh frozen tissues. Its appearance was found in 55 (72%) of examined tumors.Smac/DIABLO expression significantly correlated with tumor grade (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/4ee991dffa7844cca2de06d4e44db861 Zobrazit plný text záznamu View record in DOAJ