New non‐contrast MRI of endolymphatic hydrops in Ménière's disease considering inversion time

Autor: Masanori Ishii, Hiroshi Tanaka, Ryuichi Asai, Yasuhisa Kanai, Yujin Kato, Yusuke Ito, Fumihiro Mochizuki, Masami Yoneyama, Gail Ishiyama, Akira Ishiyama
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Laryngoscope Investigative Otolaryngology, Vol 9, Iss 4, Pp n/a-n/a (2024)
Druh dokumentu: article
ISSN: 2378-8038
DOI: 10.1002/lio2.1314
Popis: Abstract Objectives Three‐tesla MRI with gadolinium‐based contrast agents is important in diagnosing Ménière's disease. However, contrast agents cannot be used in some patients. By using the compositional difference between the inner ear endolymph and perilymph, we performed basic and clinical research focused on potassium ions and protein to find the optimal parameters for visualizing endolymphatic hydrops on MRI without contrast. We then examined the relationship between severity stage and visualization rate of endolymphatic hydrops. Methods In phantom experiments simulating the endolymph and perilymph, we explored MRI parameters that could be used to separate endolymph from perilymph by gradually changing the inversion time. We then used these parameters to perform both new non‐contrast MRI and contrast MRI on the same day in Ménière's disease patients, and we compared the visualization rates of endolymphatic hydrops under the two modalities. Fifty patients were selected from 478 patients with Ménière's disease of different severity stages; 12 patients had asthma and allergy to contrast agents. Results The higher the disease stage, the higher the endolymphatic hydrops visualization rate. The new non‐contrast MRI gave significantly higher (p
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