Protective activity of geraniol against acetic acid and Helicobacter pylori- induced gastric ulcers in rats

Autor: Subrat Kumar Bhattamisra, Vivian Lee Yean Yan, Chin Koh Lee, Chew Hui Kuean, Mayuren Candasamy, Yun Khoon Liew, Priyadarshi Soumyaranjan Sahu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Traditional and Complementary Medicine, Vol 9, Iss 3, Pp 206-214 (2019)
Druh dokumentu: article
ISSN: 2225-4110
DOI: 10.1016/j.jtcme.2018.05.001
Popis: Geraniol, an active constituent of rose and palmarosa essential oils, possesses several pharmacological properties, including antioxidant, antibacterial and antiulcer activity. Geraniol was therefore investigated for its antiulcer and anti-Helicobacter pylori activity in rats. Ulcers were induced by injecting acetic acid into the sub-serosal layer of the stomach followed by orogastric inoculation of H. pylori for 7 days. Geraniol (15 and 30 mg/kg), vehicle and a standard drug combination (amoxicillin, 50 mg/kg; clarithromycin, 25 mg/kg and omeprazole, 20 mg/kg) were administered twice daily for 14 days. All the parameters were measured at the end of treatment. The ulcer index was significantly (P
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