A simple and eco-friendly microwave mediated route the synthesis of novel antimicrobial substituted quinoline-2-thiones
| Autor: | Mohammed H. Geesi, Azzam Ahmed Mohammed AL-Hadedi, Mohammed A. Bakht, Abdellah Kaiba, Meryem Boukili, Mohammed B. Alshammari, Oussama Dehbi, Yassine Riadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Green Chemistry Letters and Reviews, Vol 11, Iss 4, Pp 469-475 (2018) |
| Druh dokumentu: | article |
| ISSN: | 1751-8253 1751-7192 17518253 |
| DOI: | 10.1080/17518253.2018.1536228 |
| Popis: | An eco-friendly and efficient method was developed for the preparation of a new series of sulfur-containing quinolinthiones. Compounds 6a–o were synthesized from 4-methyl-2-thiocoumarin and arylhydrazides using water as a solvent under microwave irradiation. Some noteworthy features of our novel method are its cleanliness, short reaction time and high conversion rate, and the reaction proceeds (profiles) using a simple procedure. All of the prepared compounds were screened for their antibacterial efficacy in vitro using the disc diffusion method against bacterial strains. Compound (6j) showed the greatest potency with a 16 and 19 mm inhibition zone against Klebsiella pneumonia and Staphylococcus aureus, respectively. |
| Databáze: | Directory of Open Access Journals |
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