| Autor: |
Laura Sánchez-Iñigo, D. Navarro-González, D. Martinez-Urbistondo, J. C. Pastrana, A. Fernandez-Montero, J. A. Martinez |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Frontiers in Endocrinology, Vol 13 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
1664-2392 |
| DOI: |
10.3389/fendo.2022.1087554 |
| Popis: |
AimsThe association between body mass index (BMI) fluctuation and BMI fluctuation rate with cardiovascular stress morbidities in a Caucasian European cohort was evaluated to ascertain the impact of weight cycling.MethodsA total of 4,312 patients of the Vascular-Metabolic CUN cohort (VMCUN cohort) were examined and followed up during 9.35 years ( ± 4.39). Cox proportional hazard ratio analyses were performed to assess the risk of developing cardiovascular stress-related diseases (CVDs) across quartiles of BMI fluctuation, measured as the average successive variability (ASV) (ASV = |BMIt0 − BMIt1| + |BMIt1 − BMIt2| + |BMIt2-BMIt3| +…+ |BMItn – 1 − BMItn|/n − 1), and quartiles of BMI fluctuation rate (ASV/year).ResultsThere were 436 incident cases of CVD-associated events involving 40,323.32 person-years of follow-up. A progressively increased risk of CVD in subjects with greater ASV levels was found. Also, a higher level of ASV/year was significantly associated with an increased risk of developing CVD stress independent of confounding factors with a value of 3.71 (95% CI: 2.71-5.07) for those in the highest quartile and 1.82 (95% CI: 1.33-2.50) for those in the third quartile.ConclusionsThe BMI fluctuation rate seems to be a better predictor than BMI fluctuation of the potential development of cardiovascular stress morbidities. The time-rated weight fluctuations are apparently more determinant in increasing the risk of a CVD than the weight fluctuation itself, which is remarkable in subjects under “yo-yo” weight patterns for precision medicine. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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