Preparation of gold-198 radioisotope and evaluation of the effect of grafting of 198Au on functionalized silica nanoparticles on its biodistribution: introducing a new theranostic agent
| Autor: | A. Rasekholghol, S.Y. Fazaeli, S. Moradi Dehaghi, P. Ashtari, M.R. Kardan, A. Joz-Vaziri, Sh. Feizi |
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| Jazyk: | perština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | مجله علوم و فنون هستهای, Vol 42, Iss 3, Pp 98-103 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1735-1871 2676-5861 |
| DOI: | 10.24200/nst.2021.1301 |
| Popis: | In this study, the influence of grafting 198Au radioisotope on functionalized silica nanoparticles with a the biodistribution of this radioisotope compare to pure gold nanoparticles, was investigated. The Au radioisotope was prepared using neutronic bombardment of a highly pure metallic gold. The prepared radioisotope was coated on silica through an interface ligand. The biodistribution suggested that the hydrophilicity of the 198Au@MCM-41 nanosilica compare to pure gold nanoparticles was higher. Through the SPECT images and %ID/g measurement, it was found that the excretion of radiotracer from the body compare to pure gold nanoparticles became faster. The Au@MCM-41 nanocomposite could potentially be used in diagnosis and therapy of cancer. |
| Databáze: | Directory of Open Access Journals |
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