Anticipating undiagnosed asthma in symptomatic adults with normal pre- and post-bronchodilator spirometry: a decision tool for bronchial challenge testing

Autor: Sheojung Shin, George Alex Whitmore, Louis-Philippe Boulet, Marie-Ève Boulay, Andréanne Côté, Céline Bergeron, Catherine Lemière, M. Diane Lougheed, Katherine L. Vandemheen, Gonzalo G. Alvarez, Sunita Mulpuru, Shawn D. Aaron
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: BMC Pulmonary Medicine, Vol 23, Iss 1, Pp 1-11 (2023)
Druh dokumentu: article
ISSN: 1471-2466
DOI: 10.1186/s12890-023-02806-9
Popis: Abstract Background Some patients with asthma demonstrate normal spirometry and remain undiagnosed without further testing. Objective To determine clinical predictors of asthma in symptomatic adults with normal spirometry, and to generate a tool to help clinicians decide who should undergo bronchial challenge testing (BCT). Methods Using random-digit dialling and population-based case-finding, we recruited adults from the community with respiratory symptoms and no previous history of diagnosed lung disease. Participants with normal pre- and post-bronchodilator spirometry subsequently underwent BCT. Asthma was diagnosed in those with symptoms and a methacholine provocative concentration (PC20) of
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